Smallpox has long been a global scourge, with more than 100 million deaths.
But for many people, it is the first vaccine that they will ever need, according to a report published today by the World Health Organization.
The report from the World Bank says that the cost of vaccinating a person against smallpox in developing countries is now $15,000 to $30,000.
The World Health Council estimates that it will cost $70,000 in the United States.
Smallpox is currently estimated to have killed more than 2.3 million people.
According to the report, the number of vaccine failures has doubled in the last two years.
About 100,000 children worldwide have been infected with smallpox, which is usually spread by close contact with infected people, but can be spread through the air, contaminated food or water and through the eyes.
The WHO said it has already spent more than $30 billion on the smallpox vaccines over the last decade.
The agency has also spent more on developing vaccines and supporting the vaccine-research community, which has produced more than 10 million doses of smallpox-related vaccines.
The World Bank report said that there are currently no plans to increase the number or size of vaccines available for use in the next few years.